影片讲述了因不明感染事件而被封锁的建筑内，孤立无援的幸存者们对抗以无法预测形态进化的感染者的故事。
讲述一个看门人被困在一个女厕所，遇到一批僵尸的攻击……
Carl Kolchak is a newspaper reporter with an abrasive personality that has gotten him fired ten times from various big-city papers. Now he's reduced to reporting for a relatively small-time paper in Las Vegas. It's here he gets the story of his life. But will the local sheriff, or the D.A., or even his own boss, let him print it? He has an ally in the FBI agent brought in to investigate this strange case. It seems someone is biting the necks of young girls and draining their blood. Can this killer with supernormal powers really be a 70-year-old Rumanian millionaire? Can he really be a vampire? And can an aging reporter do anything to stop him?
玛妮·维特森（法米克·詹森 Famke Janssen 饰）的丈夫麦克（Michael Paré 饰）是一名在外贪污受贿、在家虐待老婆的警察。由于不堪忍受长期虐打，玛妮最终将丈夫杀害。经过长达七年的牢狱生活，表现良好的玛妮获准在纽约的家中继续剩下六个月的刑期，期间她必须佩戴电子脚铐，以确保她不会超过100英尺的活动范围。然而有限的自由并未使她感到更多欢愉，她的行动被电子脚铐所限，丈夫生前的搭档山克斯（Bobby Cannavale 饰）对她憎恨不已，而这幢空旷已久的房子内又充满了复杂矛盾的回忆。 玛妮将房子打扫一新，试图展开全新的生活。但她慢慢发现，不仅痛苦的过去在牵绊着她，连丈夫那不曾安息的鬼魂也逡巡四周，纠缠不已……
