Two couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment and marriage.
故事发生在不同于现实的异世界中。在这个世界中，所有的人类均拥有被称为守护精灵的动物同伴，这些动物是人类灵魂的具象体现。女主角莱拉·贝拉奎亚成长于英国牛津的约旦学院。在她前往伦敦寻找失踪的朋友罗杰的过程中，莱拉发现一系列儿童失踪事件与神秘物质尘埃有所关联。随着故事展开，她还发现了涉及到阿斯瑞尔勋爵和玛莉莎·库尔特的危险秘密。
Cameras follow surgeons, anaesthetists, theatre staff and patients at the Queen Elizabeth Hospital Birmingham's surgical unit, where surgeons push medical boundaries to the limit.
Fran has had a pen pal named Lenny since the first grade. Fran and Lenny, through their letters, get along famously, almost like boyfriend/girlfriend. They agreed early on never to exchange photographs, but Lenny, coming to New York, wants to meet Fran in person. Maxwell is anxious to meet Lenny as he feels he's in competition with Lenny. Fran, on the other hand, is nervous to meet Lenny as she has exaggerated who "Fran Fine" is in her letters. But Fran agrees to meet Lenny at the Russian Tea Room, each identifying the other by the red rose worn on their lapels. Again, Maxwell is anxious to see Lenny, and accompanies Fran to the Russian Tea Room and stays with her until Lenny shows up. Fran and Maxwell are having a nice enough "date" of their own while they wait for Lenny, so nice that Fran almost doesn't care if Lenny shows up or not.
可怕瘟疫来袭，文明即将终结，一群人冒着失去生命、爱和人性的危险，为了生存展开残酷斗争。
